Ceruloplasmin is a ferrooxidase enzyme encoded by the CP gene in humans. Ceruloplasmin is the major copper-laden protein in the blood and is also involved in iron metabolism. It was first described in 1948.

What is the ceruloplasmin test used for?

The ceruloplasmin test is primarily used in conjunction with blood and/or urine copper tests Help diagnose Wilson diseasea rare genetic disorder associated with excessive storage of copper in the eyes, liver, brain, and other organs, as well as reduced levels of ceruloplasmin.

What does high copper levels in blood mean?

Elevated blood and urine copper concentrations and normal or elevated ceruloplasmin levels may indicate exposure to excess copper Or may be associated with diseases that reduce copper excretion, such as chronic liver disease, or diseases that release copper from tissues, such as acute hepatitis.

What causes low ceruloplasmin levels?

Low levels of ceruloplasmin can be caused by several different factors: long-term liver disease. Malnutrition (malnutrition) inability to absorb nutrients from food (malabsorption)

What if ceruloplasmin is low?

A lower-than-normal level of ceruloplasmin could mean your The body does not use or eliminate copper properly. This may be a sign of: Wilson disease. Menkes syndrome.

What does ceruloplasmin mean?

25 related questions found

What is a normal ceruloplasmin level?

normal result

The normal range for adults is 14 to 40 mg/dL (0.93 to 2.65 μmol/L). The range of normal values ​​may vary slightly from laboratory to laboratory. Some laboratories use different measurements or may test different samples.

Is low ceruloplasmin normal?

The normal range for a ceruloplasmin test is 20 to 35 mg per deciliter (mg/dL). If you have Wilson disease, your ceruloplasmin level may be less than 10 mg/dL. Low ceruloplasmin can also mean Menkes disease. This is a genetic disorder that makes it difficult for your body to absorb copper.

How is low ceruloplasmin treated?

Treatment of aceruloplasminemia mainly lies in Chelation therapy and increased serum ceruloplasmin. FFP (containing ceruloplasmin) combined with intravenous deferoxamine is effective in reducing iron levels in the liver. Repeated FFP treatment can improve neurological signs/symptoms.

What is ceruloplasmin deficiency?

ceruloplasmin deficiency is genetic disease, also known as aceruloplasminemia. Ceruloplasmin normally removes iron from cells. A deficiency of ceruloplasmin leads to abnormal deposition of iron in cells, including the pancreas, liver, retina, and basal ganglia regions of the brain.

How to increase ceruloplasmin in blood?

The ceruloplasmin must have copper attached to it to function.Its main role is to transport copper throughout the body [16]. 70% to 95% of copper in blood is bound to ceruloplasmin [17, 18]. free, Unbound copper concentration When ceruloplasmin levels are low, levels in the blood tend to increase.

How to get rid of excess copper in the body?

Some treatment options for acute and chronic copper toxicity include:

1. Chelation. Chelating agents are drugs that are injected into the blood. …
2. gastric lavage (gastric pump). This procedure uses a straw to remove the copper you eat or drink directly from your stomach.
3. drug. …
4. Hemodialysis.

How to reduce copper levels in blood?

In general, low-copper diets aim to Limit foods that are often high in copper, especially chocolates high in cocoa such as offal, shellfish, dried beans, peas, whole grains, and dark chocolate. Drinking water should be analyzed as it may contain too much copper.

What diseases can be caused by too much copper in the body?

Wilson disease is a rare genetic disorder that causes copper to build up in your liver, brain and other vital organs. Most people with Wilson disease are diagnosed between the ages of 5 and 35, but it can also affect young and old.

When should Wilson disease be suspected?

Wilson disease should be suspected If symptoms consistent with the disease are present Or if a relative is found to have the disease. Most people have slightly abnormal liver function tests, with elevated levels of aspartate aminotransferase, alanine aminotransferase, and bilirubin.

How Is Wilson’s Disease Diagnosed?

doctors usually use Blood test and 24-hour urine collection test Diagnosis of Wilson disease. Doctors may also use liver biopsy and imaging tests. For a blood test, a healthcare professional will take a blood sample from you and send the sample to a laboratory.

What blood test shows Wilson disease?

Tests and procedures used to diagnose Wilson disease include: blood and urine test. A blood test can monitor your liver function and check the level of a protein that binds copper (ceruloplasmin) in your blood and the level of copper in your blood.

What disease causes ceruloplasmin deficiency?

ceruloplasminemia It is caused by mutations in the ceruloplasmin (CP) gene. This mutation is inherited in an autosomal recessive pattern. Aceruloplasminemia is classified as a neurodegenerative disorder with brain iron accumulation (NBIA).

Where is ceruloplasmin produced?

One form, ceruloplasmin, is mainly composed of liver. It is involved in transporting iron from most of the body, but cannot enter the brain.

What is the cause of Wilson disease?

What Causes Wilson Disease?Wilson disease is Caused by genetic changes or abnormalities (mutations) in the ATP7B gene. It is an autosomal recessive disorder. This means that both parents must pass the same abnormal gene to their children.

Is ceruloplasmin a metalloprotein?

ceruloplasmin is a azurin Found in the alpha 2-globulin fraction of vertebrate plasma. It is a single-chain glycoprotein with a molecular weight of 132 000. … ceruloplasmin is similar to albumin and transferrin in that these three serum proteins are primarily considered transporters.

What happens if you are copper deficient?

Copper deficiency can cause the following problems connective tissue, muscle weakness, anemia, low white blood cell counts, neurological problems and pallor. Too much copper can be toxic.

Is copper deficiency low ceruloplasmin?

ceruloplasmin level significantly lower than Dietary copper deficiency in rodents. Comp Biochem Physiol C Toxicol Pharmacol. 2010 May;151(4):473-9. doi: 10.1016/j.

What are the side effects of too much copper?

Symptoms of copper overdose include Nausea, vomiting, bloody diarrhea, fever, stomach pain, low blood pressure, anemia, and heart problems.

How long can you live with Wilson disease?

Without treatment, life expectancy is estimated 40 yearsbut with timely and effective treatment, patients may have a normal lifespan.

Is Wilson disease an autoimmune disease?

Wilson disease (WD) should always be considered, even if the case met the simplified criteria for autoimmune hepatitis (AIH). Although rare, there have been a few case reports of WD with high titers of autoantibodies and gamma globulin. So it may resemble the typical behavior of AIH.