Cardiotoxicity of trastuzumab is considered to be Consequences of HER2-mediated attenuation of cardiac signaling, ultimately resulting in decreased cardiomyocyte function. HER2 appears to function as a compensatory mechanism against cardiac stress, such as anthracycline-induced cardiotoxicity.

Why does Herceptin cause heart problems?

During Herceptin treatment, it is recommended to use for one year, Toxicity can cause the heart to become too weak to pump blood. All patients on Herceptin undergo regular heart tests, such as echocardiograms, to look for possible heart damage.

Does Herceptin cause cardiotoxicity?

Likewise, the final analysis of the Herceptin adjuvant trial also reported Cardiotoxicity is much lower Secondary cardiac endpoints (New York Heart Association-defined grade I or II toxicity) occurred in 7.25% of the 2-year trastuzumab group and 4.4% of the 1-year trastuzumab group [16].

How does Herceptin affect the heart?

One of the known side effects of the breast cancer drug trastuzumab (Herceptin) is that it damages the heart and its ability to pump blood efficientlysometimes causing mild heart failure, including shortness of breath and chest pain.

Why does trastuzumab affect the heart?

According to the package insert, trastuzumab may cause « Left Ventricular Dysfunction, Arrhythmias, Hypertension, Disabling Heart Failure, Cardiomyopathy, and Cardiac Death. » Cardiac dysfunction is the most common side effect in clinical practice and is the focus of this brief review.

JACC: Cardio-Oncology Video Case Presentation: Cardiotoxicity During HER2 Targeted Therapy

27 related questions found

Is Herceptin’s Heart Damage Permanent?

Some women taking Herceptin lose heart function during treatment. In rare cases, heart failure can occur. Heart function can recover after Herceptin treatment is stopped.

What are the long-term effects of Herceptin?

heart problems, including Myocardial damage and heart failure, is a possible side effect of Herceptin. So doctors wondered whether treating early-stage HER2-positive breast cancer with Herceptin could cause long-term heart problems, or whether the problems would go away after a woman stopped taking Herceptin.

Does Herceptin weaken your immune system?

Does trastuzumab (Herceptin) affect the immune system?Taking trastuzumab (Herceptin) may mean youYou are more likely to have coronavirus or become very sick if: you understood. The risk may be higher if you are receiving chemotherapy.

How long can you stay on Herceptin?

official answer.This regimen can be continued when Perjeta (generic name: pertuzumab) and Herceptin (generic name: trastuzumab) are used as adjuvant therapy (postoperatively) for the treatment of HER2+ early breast cancer Every 3​​ weeks a year (up to 18 cycles).

Why is Herceptin taken for a year?

Since 2005, the standard of care is to give Herceptin for 1 year after surgery, Chemotherapy to reduce the risk of early recurrence (cancer recurrence), HER2-positive breast cancer. Like most cancer treatments, Herceptin can cause side effects, including possible heart damage.

Can Herceptin cause kidney damage?

Kidney problems: this Medications that can cause decreased kidney function or kidney damage. Therefore, your healthcare team will monitor your kidney function with blood tests while you are receiving trastuzumab. Due to changes in kidney function, some patients need to stop taking the drug.

Can Herceptin cause lung damage?

lung problems

Herceptin May cause lung inflammation, which may be life-threatening. Symptoms include difficulty breathing, cough, tiredness, and fluid buildup in the lungs.

Can Herceptin cause AFIB?

Notably, women who received chemotherapy had a higher rate of atrial fibrillation (adjusted HR, 1.23; 95% CI, 1.13-1.35); however, this rate was significantly higher than those exposed to anthracyclines or trastuzumab ( Herceptin) is irrelevant.

What does Herceptin do to your body?

Herceptin can Helps control the growth of cancer cells containing high levels amount of human epidermal growth factor receptor 2 (HER2). HER2 is present in all human cells. It controls cell growth and repair.

What is the success rate of Herceptin?

Women who received Herceptin had better overall survival 10 years after treatment: 84% of women who received chemotherapy plus Herceptin were alive. 75.2% of women who received chemotherapy alone are alive.

Will my hair grow back while taking Herceptin?

Your hair may thin, but you’re unlikely to lose all of it. This usually starts after your first or second cycle of treatment.it is almost always temporary Your hair will grow back after the treatment.

What happens after Herceptin treatment ends?

After treatment, Your doctor will check your heart every 6 months for at least 2 years. Get emergency medical help if you are taking Herceptin and have any symptoms of heart failure. They include: shortness of breath.

Is Herceptin a form of chemotherapy?

Herceptin is an intravenous drug that belongs to chemotherapy Options to prevent breast cancer from coming back, and to treat breast cancer that has spread beyond the breast (metastasis). It belongs to a class of drugs called monoclonal antibodies.

Is Herceptin a good medicine?

Intravenous Herceptin is FDA-approved for: Treatment of advanced HER2– Positive breast cancer. Reduce the risk of recurrence Early-stage, HER2-positive breast cancer has a high risk of recurrence.

Can chemotherapy permanently damage the immune system?

Now, new research shows that Effects of chemotherapy may damage parts of immune system for up to nine months after treatmentleaving patients vulnerable to infection — at least for patients with early-stage breast cancer who have received some type of chemotherapy.

How long does it take for the immune system to recover after radiation therapy?

might need From 10 days to several months Allow the immune system to fully recover. Surgery also destroys the skin and may damage the mucous membranes and tissues under the skin, exposing it to bacteria.

Is Herceptin Immunotherapy or Chemotherapy?

Herceptin is a Targeted therapy against cancer The drugs are called monoclonal antibodies. Herceptin is used to treat HER2-positive cancers in adjuvant breast cancer, metastatic breast cancer, and metastatic gastric cancer.

Is HER2-positive relapse possible?

Two studies find that even small (1 cm or less) early-stage HER2-positive breast cancer more likely to come back (relapse) and spread to parts of the body farther from the breast (metastasis) than early, small HER2-negative breast cancer.

Does Herceptin Cause Depression?

Frustrated.Some People taking Herceptin may be depressedIn clinical trials, depression has been reported in 6 to 20 percent of people taking Herceptin for breast cancer.

What are the long-term side effects of breast radiation therapy?

Long-term side effects may include:

• Breast changes: Breasts may shrink or become denser after radiation therapy. …
• Brachial plexopathy: Radiation to the breast or chest wall can sometimes damage the nerves that run through the arms, wrists, and hands. …
• Lymphedema: Lymphedema is swelling of the arms, hands, or chest.