While mild muscle pain is a relatively common side effect of statins, some people taking statins to lower their cholesterol may experience severe muscle pain. This severe pain may be a symptom of rhabdomyolysis (rab-doe-my-OL-ih-sis), a rare disorder that causes muscle cells to break down.

Which statins cause the most rhabdomyolysis?

Simvastatin was the most common statin reported in association with rhabdomyolysis (55 patients), and the most common dose was 40 mg/day. Atorvastatin was the second most common drug (20 patients) at a dose of 10 mg/day.

How do statins cause rhabdomyolysis?

However, the myotoxic mechanism of action of statins is unclear.statins Inhibits mevalonate biosynthesis, the rate-limiting step in cholesterol synthesis, by inhibiting HMG-CoA reductase. Mevalonate is also an essential precursor for the production of isoprenoids such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate.

How do you know if you have muscle damage from statins?

muscle pain and injury

One of the most common complaints of people taking statins is muscle pain.you may feel this pain Muscle soreness, tiredness, or weakness. Pain can be mild discomfort or severe enough to make your daily activities difficult.

Which statin causes the least rhabdomyolysis?

Any statin can cause any muscle symptoms – from mild myalgia to rhabdomyolysis. Fluvastatin and Pravastatintwo relatively ineffective statins not metabolized by CYP3A4, had the lowest risk of rhabdomyolysis; high-dose simvastatin (80 mg) had the highest risk.

Statin-Induced Myopathy | UPMC

22 related questions found

Which statin has the least side effects for muscles?

Hydrophilic statins, including rosuvastatin (Crestor®) and Pravastatin (Pravachol®), must be actively transported and reduce muscle pain.

What foods should I avoid while taking statins?

A: Avoid high-fat and high-cholesterol foods as part of your overall treatment while taking atorvastatin (Lipitor).you should avoid plenty of grapefruit or grapefruit juice, which can increase the risk of serious side effects. Also, avoid drinking too much alcohol, as this can cause serious liver problems.

How long does it take for statin-induced muscle pain to go away?

In most cases, if you experience muscle pain from a statin, you will notice it as soon as you start taking it.If you can live with the discomfort, it is best to continue taking your statin as prescribed at least 2 to 3 weeks. Side effects may go away as your body adjusts to the medication.

Which vitamins should not be taken with statins?

A sort of Contains magnesium and aluminum Antacids have been reported to interfere with the absorption of atorvastatin. People can avoid this interaction by taking atorvastatin two hours before and after any aluminum/magnesium-containing antacid. Some magnesium supplements such as magnesium hydroxide are also antacids.

At what age should statins be stopped?

Guy L. Mintz, MD, chief of cardiovascular health and lipidology at Northwell Health’s Sandra Atlas Bass Heart Hospital in Manhasset, N.Y., said the study reinforces that older adults should not be « The Age of Magic » at 75.

Which drugs cause rhabdomyolysis?

statins is the only class of drugs that commonly causes skeletal muscle damage, especially when combined with drugs that interact at the pharmacokinetic level.

What are the most common life-threatening complications of rhabdomyolysis?

The most serious late complication is acute renal failure, which occurs in about 15% of people with the syndrome. Early recognition of rhabdomyolysis and prompt management of complications are critical to a successful outcome.

How long does it take to recover from rhabdomyolysis?

If the condition is identified and treated early, you can avoid most major complications and expect a full recovery.Recovering from exercise-induced rhabdomyolysis without major complications can be taken weeks to months Allow the patient to resume exercise without relapse of symptoms.

What can you use instead of statins?

7 Cholesterol-Lowering Alternatives to Statins

• Bet class. Mainly used to lower levels in patients with very high triglyceride levels that can lead to pancreatitis. …
• Plant stanols and sterols. …
• Cholestyramine and other bile acid binding resins. …
• niacin. …
• Eicosanol. …
• Red Yeast Rice Extract (RYRE)…
• natural product.

Are there non-statin cholesterol medications?

Your doctor may prescribe many non-statin medications: Bile acid binding resincholestyramine (Locholest, Prevalite, Questran), colesevelam (WelChol), and colestid (Colestid) stick to cholesterol-rich bile acids in the gut and lower LDL levels.

Do statins destroy muscle tissue?

Myth: Statins damage muscle tissue.

« Most studies show that Few patients actually stop taking statins due to side effects. It is very rare to develop a more serious muscle damage called rhabdomyolysis. « 

Do statins make you age faster?

So, while these findings are interesting and potentially important, the conclusions drawn from these studies on crushed fat cells are Statins cause premature aging.

Can I take vitamin D while taking statins?

The effect of vitamin D on statins

A small 2016 study concluded that people with low vitamin D levels were more likely to experience muscle-related side effects from statins. Vitamin D supplementation improves statin tolerance.

Can I take vitamin D and statins?

Rosuvastatin (Crestor) increases vitamin D levels in the blood by about three times. Atorvastatin (Lipitor) has a similar effect on vitamin D as rosuvastatin. Other statins, such as lovastatin (Mevacor) and simvastatin (Zocor), can also increase the concentration of vitamin D in the blood.

Can I stop statin cold turkey?

Some people can safely stop taking statins, but is especially dangerous for others. For example, if you have a history of heart attack or stroke, it is not recommended that you stop taking these drugs. This is because you are more likely to experience other such problems when you stop taking statins.

What helps statin-induced muscle pain?

take Supplements.

If you have low levels of vitamin D in your blood, bringing it back to normal with supplements may help reduce muscle pain and cramps. Some people find that CoQ10 can relieve symptoms.

Is statin damage reversible?

Much of the muscle damage caused by statins is secondary to their direct toxic effects, possibly through coenzyme Q10 depletion leading to mitochondrial dysfunction.This Injury is dose-dependent and reversible upon discontinuationMost symptoms resolve within 2-3 months (3).

Can you eat oranges on statins?

Limit your grapefruit consumption or switch to « safeCitrus fruits such as blood oranges, mandarins, lemons, limes, mandarins, navel oranges, and tangerines. Bitter oranges, grapefruits, tangerines, and Seville oranges contain high levels of furanocoumarins and should also be avoided.

Can I drink coffee while taking atorvastatin?

In this elegant study, they showed that 3-day treatment with atorvastatin reduced infarct size, while concurrent administration of caffeinated coffee completely eliminated infarct size, but decaffeinated coffeein a drinking bottle [7].

Do statins make you fat?

Like many drugs, statins can cause side effects, including digestive problems, muscle pain and weakness, and cognitive impairment.Another side effect associated with statins is weight gain.