Classical isosteres are molecules or ions that have similar shapes and often have electronic properties. There are many definitions available. But the term is often used in the context of biological activity and drug development. Such biologically active compounds containing isosteres are called bioisosteres.

What does Isostere mean?

: one of two or more substances such as carbon monoxide and molecular nitrogen Due to having the same number of total electrons or valence electrons in the same arrangement, it exhibits similarities in certain properties And consists of different atoms, not necessarily the same number of atoms.

What are examples of Isosteres?

Isosteres are similarly sized atoms, molecules or ions containing the same number of atoms and valence electrons. … Example 1. Consider neonthe noble gas at the end of the second row of the periodic table.

What is the difference between classical and non-classical isosteres?

Classical isosteres typically retain many of the same structural properties, while non-classical isosteres are more dependent Depending on the specific binding needs of the ligand in question, cyclic moieties can be substituted with linear functional groups, complex heteroatom moieties with alkyl groups, or other…

What is the difference between isosteric and biological isosteric?

Friedman (1951): A biological isostere is an atom or molecule that meets the broadest definition of isostere, have the same type of biological activity. Thornber (1979): Groups or molecules with chemical and physical similarities produce broadly similar biological effects.

What is an equidistant line? (Chemistry Online Master)

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