Bilirubin formation About 80% of bilirubin is made from the breakdown of hemoglobin in the body aging Red blood cells and premature destruction of red blood cells in the bone marrow. The rest comes from the turnover of various heme-containing proteins found in other tissues, mainly liver and muscle.

What is bilirubin formed from?

Bilirubin is a brownish-yellow substance found in bile.it is produced when the liver breaks down old red blood cells. Bilirubin is then removed from the body through feces (feces), giving the stool its normal color.

Where is hemoglobin broken down into bilirubin?

Bilirubin is the brownish-yellow pigment of bile, secreted by bile liver In vertebrates, it gives solid waste (feces) its characteristic color. It is produced in bone marrow cells and the liver as the final product of the breakdown of red blood cells (hemoglobin).

What converts heme to bilirubin?

Senescent red blood cells are mainly phagocytosed and degraded by macrophages in the spleen and liver. In these cells, heme is first converted to bilirubin in a two-step enzymatic process that employs « biliverdin » as an intermediate…then macrophages excrete the produced bilirubin into the plasma.

How is conjugated bilirubin formed?

In the bloodstream, unconjugated bilirubin binds to albumin to facilitate its transport to the liver. Once in the liver, glucuronyltransferase adds glucuronic acid to unconjugated bilirubin. This forms soluble conjugated bilirubin.

Bilirubin metabolism simplified

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